National Institutes of Health Proteostasis Scientific Interest Group

Proteostasis (Protein Homeostasis) Scientific Interest Group

Proteostasis (protein homeostasis) is essential for cell health, viability, adaptation to environmental challenges and ultimately, life. Derailed proteostasis leads to protein misfolding and aggregation that is the underlying origin of many devastating human disorders including cancer, neurodegenerative diseases, diabetes, cystic fibrosis, alcoholic liver disease, cataract, cardiomyopathy, immune problems, aging and other chronic maladies. The Proteostasis (Protein Homeostasis) Network (PN) supports protein health by proper protein synthesis, folding, trafficking and disposal through its cardinal components the Heat Shock Response (HSR), the Unfolded Protein Response (UPR), the Ubiquitin-Proteasome System (UPS), and autophagy.

Deciphering the principal rules of the Proteostasis Network (PN) is critically important in the understanding of human health and disease that spans over the interest of basically all NIH ICs. The new "Proteostasis" SIG (PSIG) provides a forum to facilitate interaction, communication and collaboration among researches working on different areas of the Proteostasis Network both in the intramural community and outside NIH. Planned activities include the inaugural meeting in March 2013 and bimonthly seminars by leaders of the field.

For more information about the PSIG, contact Andras Orosz at Join the Proteostasis LISTSERV at

National Institutes of Health (NIH), 9000 Rockville Pike, Bethesda, Maryland 20892.
  Department of Health and Human Services - Government made easy