|
|
| |
Translational Research Interest Group
Our Theme: Bench to Bedside & Back
The purpose of the Translational Research Interest Group (TRIG) is to bring together physician scientists and basic research scientists to discuss efficient ways of accelerating the application of biomedical discoveries to clinical practice, ultimately for the benefit of patients. Conversely, it is also aimed to promote the translation of clinical observations to the development of improved preclinical strategies and disease models. The TRIG coordinates seminars and workshops to help bridge the gap between laboratory research and clinical applications. It also suggests topics and speakers for the Annual NIH Research Festivals, and nominates speakers for the NIH Wednesday Afternoon Lecture Series.
NIH intramural and extramural scientists are invited to become members of the TRIG. The invitation to join the TRIG is extended to staffs at the Food and Drug Administration and other Federal Government Agencies, and scientists from the extramural research community outside of Government. Please join our listserv and also add your name to our member list.
TRIG events are announced through the listserv and this website. The TRIG Chair is Minkyung (Min) Song.
Events in 2011-2012:
Visit "Meetings and Seminars" for complete schedule of the TRIG-hosted events and abstracts of lectures.
NIH Translational Research Interest Group Lecture Series
May 10, 2012 (Thursday) 1-2 p.m., Bldg. 50 Room 1227/1233 Lobby
Kenneth A. Jacobson, PhD
Chief, Laboratory of Bioorganic Chemistry; Chief, Molecular Recognition Section, NIDDK
“A3 Adenosine Receptor Modulators: Structure-Based Design and Application to Inflammatory Disease, Glaucoma, Ischemia, and Cancer”
*********************************************************
NIH Translational Research Interest Group Lecture Series
April 12, 2012 (Thursday) 1-2 p.m., Bldg. 10 (Clinical Research Center) Lipsett Amphitheater
Thomas E. Wellems, MD, PhD
NIH Distinguished Investigator;
Chief, Laboratory of Malaria and Vector Research, NIAID;
Elected Member, U.S. National Academy of Sciences;
Elected Member, Institute of Medicine of the U.S. National Academies
“Drug-resistant Malaria: Determinants of Treatment Outcome and Prospects for Control”
*********************************************************
NIH Translational Research Interest Group Lecture Series
March 8, 2012 (Thursday) 1-2 p.m., Bldg. 10 (Clinical Research Center) Lipsett Amphitheater
Irwin M. Arias, MD
Senior Scientist, Head, Unit of Cellular Polarity, Cell Biology and Metabolism Branch, NICHD;
Coordinator of the NIH “Demystifying Medicine” Course;
Professor of Medicine (Emeritus), Albert Einstein College of Medicine;
Professor/Chairman of Cellular and Molecular Physiology (Emeritus) and Professor of Medicine, Tufts University School of Medicine
“Serendipity and Journeys through the Hepatocyte”
*********************************************************
NIH Translational Research Interest Group Lecture Series
February 16, 2012 (Thursday) 1-2 p.m., Bldg. 50 Room 1227/1233 Lobby
Shioko Kimura, PhD
Head, Endocrinology Section, Laboratory of Metabolism, NCI
“Anti-inflammatory, growth factor and anti-fibrotic activities of Secretoglobin (SCGB) 3A2: Possible clinical applications”
*********************************************************
NIH Translational Research Interest Group Lecture Series
January 12, 2012 (Thursday) 1-2 p.m., Bldg. 50 Room 1227/1233 Lobby
Daphne W. Bell, PhD
Head, Reproductive Cancer Genetics Section, Cancer Genetics Branch, NHGRI
Recipient of the 2007 Presidential Early Career Award for Scientists and Engineers
“The Genetics and Genomics of Clinically Aggressive Endometrial Cancers: Searching for new therapeutic targets”
*********************************************************
NIH Translational Research Interest Group Lecture Series
December 8, 2011 (Thursday) 1-2 p.m., Bldg. 10 (Clinical Research Center) Lipsett Amphitheater
Daniel Kastner, MD, PhD
Scientific Director, Division of Intramural Research, NHGRI
NIH Distinguished Investigator, Medical Genetics Branch, NHGRI
“Cutting Gordian Knots at the Pools of Bethesda: Adventures in the Genomics of Inflammation”
*********************************************************
Forum on “NIH Resources for Discovery and Development of Therapeutic Candidates”
November 3, 2011 (Thursday) 1:00-3:45 p.m., Bldg. 10 Lipsett Amphitheater
Minkyung (Min) Song, PhD
Program Director, Division of Cancer Treatment and Diagnosis, NCI
"Introduction"
Christopher P. Austin, MD
Director, NIH Center for Translational Therapeutics
“Translational Therapeutics Development at NIH”
Ajay Pillai, PhD
Program Director, Computational Science, NHGRI
“Overview of Chemical Biology Databases with Focus on Using Molecular Libraries Data”
James P. Boyce, PhD
Program Officer, Division of Microbiology and Infectious Diseases, NIAID
“Resources for the Microbiology and Infectious Disease Research Community”
Jill Heemskerk, PhD
Program Director, Office of Translational Research, NINDS
“Blueprint Neurotherapeutics: A Virtual Pharma Model”
Robert DeChristoforo, RPh, MS, FASHP
Chief, Clinical Center Pharmacy Department, CAPT USPHS (Ret.), CC
“Clinical Center Pharmacy's Role in the Repurposing of Drugs”
Peter Herscovitch, MD
Director, Positron Emission Tomography Department, CC
“Positron Emission Tomography Resources for Drug Discovery and Development”
Harvey G. Klein, MD
Chief, Department of Transfusion Medicine, CC
“Cell Processing Facilities Supporting Transfusion and Regenerative Medicine”
Barbara Mroczkowski, PhD
Special Assistant, Office of the Director, Division of Cancer Treatment and Diagnosis, NCI
“NCI Experimental Therapeutics (NExT) Program”
Shivaani Kummar, MD
Head, Developmental Therapeutics Clinic, NCI
“Clinical Development of Therapeutic Candidates at NCI”
Sheryl Ruppel
Director of Regulatory Affairs, Biopharmaceutical Development Program, SAIC-Frederick Inc., NCI-Frederick
“Regulatory Requirements and Resources for Getting to an Investigational New Drug (IND) Filing with the FDA”
*********************************************************
2011 NIH Research Festival
October 24, 2011 (Monday) 2:00-4:00 p.m.
Natcher Conference Center Room E1/E2
Symposium on "Advances in Immune Targeted Therapies"
Co-Chairs: Liliana Guedez, PhD, NCI, and Shaden Kamhawi, PhD, NIAID
Immunology-based technologies have significantly contributed to the development of therapies modulating the immune system. It is timely to discuss transfer of genetically modified T-cells, vaccines, genetically engineered antibodies and interleukins as some of the promising fronts in the war against many diseases. This symposium topic is of broad interest to NIH intramural investigators who have been leaders in the development and translational research of targeted immune therapeutics. As the results from clinical trials are provided, new and unexpected information is revealed as well as some mechanistic differences between pre-clinical models and humans are reported. This symposium will serve as a scientific platform to exchange cutting-edge clinical information on issues related to the immunotherapies, to know about the challenges encountered in the clinic, and to discuss experimental approaches on how to improve the clinical translation of therapies modulating the immune system.
Program
Nicholas Restifo, MD, NCI
"Recent Developments in T-cell Adoptive Immunotherapy for Cancer Treatment"
Ravi A. Madan, MD, NCI
"Therapeutic Cancer Vaccines Combined with Standard Therapies in the Treatment of Human Carcinoma"
Alan Wayne, MD, NCI
"Bench to Bedside Development of anti-CD22 Immunotoxins for Childhood Acute Lymphoblastic Leukemia"
Bibiana Bielekova, MD, NINDS
"Clinical Translation of Daclizumab for the Treatment of Multiple Sclerosis"
Joanna Fares, NCI, FARE Award Winner
"Modulation of Myeloid-Derived Dendritic Cell Maturity: Unmasking a Novel Role for the Tumor Suppressor p15Ink4b in Immunity"
***************************************************
2011 NIH Research Festival
October 24, 2011 (Monday) 2:00-4:00 p.m.
Natcher Conference Center Balcony A
Symposium on "Informing Therapeutic Interventions with Mechanism-Based Pharmacology and Toxicology"
Co-Chairs: Minkyung (Min) Song, PhD, NCI, and Juan Lertora, MD, PhD, CC
It is essential to translate mechanisms of drug action and toxicity into efficient discovery and development of safe and effective therapeutics. Elucidation of molecular mechanisms underlying disease pathogenesis and differential responses to drugs in individual patients will inform rational development of therapeutic interventions. Such research efforts will allow scientists to contribute to reducing late-stage drug attrition due to unanticipated toxicity or lack of clinical efficacy. During this symposium, the speakers will discuss:
• Mechanism-based repurposing of an agent for potential treatment of various liver diseases;
• Development of therapeutic strategies and novel bioactive substances by understanding molecular pharmacology and toxicology of candidate agents;
• Mechanisms of microbial drug resistance within the host;
• Incorporation of molecular characteristics and biological functions of therapeutic targets during the discovery of drug candidates;
• Identification of somatic activating mutations in the disease pathway to inform targeted therapies; and
• Use of positron emission tomography tracers as molecular imaging probes to guide the development of therapeutic interventions.
Program
Bela Horvath, MD, PhD, NIAAA, FARE Award Winner
"Role of Poly (ADP-Ribose) Polymerase 1 (PARP-1) in Liver Injury, Inflammation and Fibrosis"
William D. Figg, PharmD, NCI
"Bench to Bedside and Back to the Bench: Development of Novel Therapeutic Agents"
June Kwon-Chung, PhD, NIAID
"The Relationship between Cryptococcal Adaptation to Azole Drugs and Azole Therapy Failure"
Kenneth A. Jacobson, PhD, NIDDK
"Therapeutic Interventions Based on G Protein-Coupled Receptors for Extracellular Nucleosides and Nucleotides"
Daphne W. Bell, PhD, NHGRI
"Somatic Activating Mutations in the PI3K Pathway Informing Targeted Therapies of Endometrial Cancer"
Robert B. Innis, MD, NIMH
"Positron Emission Tomography: A Tool to Study Pathophysiology and to Facilitate Therapeutic Drug Development"
*********************************************************
NIH Translational Research Interest Group Lecture Series
October 6, 2011 (Thursday) 1-2 p.m., Bldg. 10 (Clinical Research Center) Lipsett Amphitheater
Issam Zineh, PharmD, MPH, FCCP
Associate Director for Genomics, Office of Clinical Pharmacology;
Co-Director, Biomarker Qualification Program, Office of Translational Sciences
Center for Drug Evaluation and Research, Food and Drug Administration
"Pharmacogenomics from Promise to Policy"
*********************************************************
NIH Translational Research Interest Group Lecture Series
September 15, 2011 (Thursday) 1-2 p.m., Bldg. 10 (Clinical Research Center) Lipsett Amphitheater
Hamilton Moses, III, MD
Chairman, The Alerion Institute; Adjunct Professor in Neurology, Johns Hopkins School of Medicine
"What is the Role of Biomedical Research in the 21st Century?"
If you encounter problems on this site or have questions, send e-mail to the NIH SIG Administrator.
|
|
|
|