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Member Bulletin Board
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| Job Notices
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Two research positions (postdoctoral level) will be available (mid June 2009) in the area of neurophysiology and epigenetics of barrel cortex to work with Dr. Zygmunt Galdzicki.
The research involves the use of electrophysiological (slice patch-clamp), optical (two-photon fluorescence microscopy, intrinsic signal optical imaging) and molecular techniques to investigate the role of signal transduction pathways affecting somatosensory processing, chromatin properties and synaptic plasticity of neuronal networks.
These positions are located in the Uniformed Services University, School of Medicine, Department of Anatomy, Physiology and Genetics across the street from the National Institutes of Health. Teaching opportunities are available for those fellows who desire them. For further information about research and financial benefits please contact:
Zygmunt Galdzicki, PhD
Department of Anatomy, Physiology and Genetics
Uniformed Services Medical School
Bethesda, MD 20814
4301 Jones Bridge Rd.
tel: 301-2956587
fax: 301-2953566
e-mail: zgaldzicki@usuhs.mil
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Chief, Visuomotor Disorders Section, Laboratory of Sensorimotor Research, NEI |
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Chief, Visuomotor Disorders Section Laboratory of Sensorimotor Research, NEI (deadline: open-ended) The National Eye Institute (NEI) seeks an outstanding clinician scientist for a tenured or tenure-track position as Chief, Visuomotor Disorders Section in the Laboratory of Sensorimotor Research (LSR) in the Division of Intramural Research. This recruitment is directed towards clinicians with expertise in central disorders that affect vision and/or eye movements (including disorders of binocular function). The post offers a unique opportunity for a talented individual to provide strong and stimulating leadership in an organization dedicated to uncovering new scientific knowledge, both laboratory and clinical. We welcome the full range of candidates at all levels. The Laboratory of Sensorimotor Research is devoted to understanding the organization of the brain related to the control of eye movements, visual perception and their disorders. The Visuomotor Disorders Section Chief is expected to create a vigorous research program dedicated to elucidating the role played by these brain mechanisms in human disease, and to explore treatments. The Chief will develop broad investigational plans, independently and in collaboration with other NEI investigators and research scientists in the United States and abroad. The Chief will examine and treat patients, as well as design, implement and conduct research and clinical protocols. An opportunity exists for the Section Chief to recruit staff and supervise training. The NEI provides an exceptional environment for clinical research including the infrastructure necessary for patient recruitment, a clinical protocol development group, and a Contract Research Organization that provides statistical and epidemiological expertise, data management and analysis, study monitoring, regulatory guidance, and overall operational support. The NIH Clinical Center provides additional access to exceptionally broad medical and diagnostic resources. In addition, the LSR provides exceptional support for more specialized needs, such as the measurement of eye movements and computational analysis/modeling. The position requires an ability to integrate basic, clinical and translational research, and create an intellectual synergy and an environment for state-of-the art patient care for those suffering from visual dysfunction. At a minimum, candidates should have a Doctor of Medicine degree from a school in the U.S. or Canada approved by a recognized accrediting body in the year of the applicant's graduation, or a Doctor of Medicine or equivalent degree from a foreign medical school which provided education and medical knowledge substantially equivalent to accredited schools in the United States. Candidates should be Board-certified, board eligible or equivalent, have direct clinical experience. Salary is commensurate with research experience and accomplishments. A full Federal package of benefits is available (including retirement, health, life and long term care insurance, Thrift Savings Plan etc). Applicants should submit curriculum vitae, bibliography, copies of their five most significant publications, a summary of research accomplishments and three reference letters. Applicants should also submit a written statement with their perspective on the needs and opportunities necessary to move from the basic understanding of brain mechanisms supporting vision and eye movements to clinical therapeutic interventions and improved patient care. This statement should indicate how the applicant's particular expertise and background could contribute to this transition. Applications should be sent to: Mica Gordon, Executive Assistant, Office of the Scientific Director, National Eye Institute, Building 31, Room 6A22, 31 Center Drive, Bethesda, MD 20892; Tel: 301-451-6763, Email: gordonmi@nei.nih.gov. NIH is dedicated to building a diverse community in its training and employment. NIH is a part of the U.S. Department of Health and Human Services. |
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Cold Spring Harbor Postdoctoral positions to study autism in genetic mouse models |
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Postdoctoral positions to study autism in genetic mouse models We are seeking postdoctoral fellows interested in studying disruptions in neural circuits in genetic mouse models of autism. Autism spectrum disorders (ASDs) are among the most heritable neuropsychiatric disorders, and many genes have been implicated in their etiology. Our research focuses on the identification and analysis of brain regions, neural circuits and connectivity pathways that are disrupted in genetic mouse models of autism. We hypothesize that: 1) the heterogeneous collection of autism candidate genes leads to more homogeneous "core" disruptions of neural circuitry, and 2) identification of such deficits will provide a neural circuit-based classification of autism, revealing one or several neural circuit pathologies as key targets for detailed mechanistic studies and therapeutic development. Our approach is based on building a “pipeline” of anatomical and functional methods for analysis of neural circuits in a mouse brain. These methods include high-throughput microscopy for whole mouse brain imaging, viral vector-based anatomical tracing, transgenic and knock-in “indicator” mouse lines for monitoring expression of activityregulated genes, and both in vitro and in vivo two-photon imaging and electrophysiology. We collaborate closely with other CSHL teams focused on the problem of autism, including human geneticists uncovering disrupted loci in autism (Michael Wigler lab) and mouse geneticists engineering animal models with replicas of the human lesions (Alea Mills lab). Candidates should be skilled experimentalists, highly motivated, and able to work in an interdisciplinary environment. Strong background in at least one of the following areas is required: mouse genetics, microscopy, molecular neurobiology, electrophysiology, and neuroanatomy. If interested please e-mail your CV and contact information for three references to: Pavel Osten osten@cshl.edu Associate Professor Cold Spring Harbor Laboratory |
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Director of Electrophysiology Lab at Eli Lilly |
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We are currently recruiting a lab head (analogous to an assistant professor) to direct an electrophysiology lab in our psychiatric disorders research group. The position is based in either Indianapolis, Indiana or Surrey, UK. This scientist will oversee a lab of technicians and / or postdoctoral follows employing cellular, slice, and / or in vivo recording to study neurons and circuits. He/she will help define the receptors and pathways that underlie the neuropharmacology of psychiatric disorders. This individual will also lead cross-functional project teams including chemists, toxicologists and affiliated scientists. Lilly has the industry leading neuroscience franchise, which comprises blockbuster products for psychiatric disorders including Zyprexa for schizophrenia and bipolar disease, Cymbalta for depression, anxiety and diabetic peripheral neuropathic pain, Strattera for ADHD, Symbyax for bipolar depression, and our legacy product Prozac. The electrophysiology lab head will participate in the discovery and characterization of Lilly’s next generation of breakthrough neuropsychiatric medicines. If interested, please contact David S. Bredt, M.D., Ph.D. Vice President, Neuroscience Discovery and Clinical Investigation Lilly Research Laboratories, Corporate Center Indianapolis, IN 46285 (P) 317-276-0011 (F) 317-276-7600 BREDT_DAVID@LILLY.COM ** posted by John Isaac ** |
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Postdoc position to work on AMPA receptors at LMB, University of Cambridge UK |
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Postdoc position to work on glutamate receptor trafficking mechanisms at University of Bristol, UK |
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Research Assistant/Associate (Three posts) (vacancy ref. 14525) Three prestigious European Research Council (ERC) funded research positions are available in the lab of Professor Jeremy Henley to investigate the pathways and functions of SUMOylation in healthy and diseased neurones. Projects will include: • Investigation of the regulation and activity-dependence of extranuclear SUMOylation pathways • identification, validation and characterisation of novel SUMOylated target proteins • definition of the roles of SUMO in protein trafficking and stability • assessment of SUMO in synaptic function, structure and plasticity • determination of the potential neuroprotective effects of protein SUMOylation You should be motivated, ambitious and have, or be working towards, a PhD in a relevant discipline together with excellent communication skills. All interested candidates are encouraged to apply but preference may be given to candidates with experience in live and fixed cell confocal imaging and/or ubiquitination/SUMOylation pathways. In addition to general molecular and biochemical techniques, expertise immunocytochemistry and immunoelectron microscopy would be an advantage. If successful, you may be appointed either on a fixed term or a permanent contract depending on the extent of your previous relevant research experience. Further information can be found at http://www.bristol.ac.uk/personnel/ftc/ Grade: Level a - Level b in Pathway 2 Salary: £29,704-£33,432 Contact: Professor Jeremy Henley: J.M.Henley@bristol.ac.uk: Tel: 0117 331 1945 Please submit applications by: 09 February 2009 Relevant references: S. Martin, A. Nishimune, J. Mellor and J.M. Henley. (2007) SUMOylation regulates kainate receptor mediated synaptic transmission. Nature. 447, 321-5 S. Martin, K.A. Wilkinson, A. Nishimune and J.M. Henley (2007) Emerging roles for protein SUMOylation in neuronal function and dysfunction. Nature Reviews in Neuroscience 8, 948-59. H. Cimarosti and J. M. Henley (2008) Investigating the mechanisms underlying neuronal death in ischaemia using in vitro oxygen-glucose deprivation: potential involvement of protein SUMOylation. The Neuroscientist. 14, 626-36. |
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seeking a Ph.D.-level neuroscientist |
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We are seeking a Ph.D.-level neuroscientist to evaluate the pharmacological action of drug candidates on membrane excitability and synaptic transmission in disease relevant models of neuropathic and inflammatory pain. A strong background in the use of in vitro (patch clamp, sharp electrode intracellular, or extracellular recordings) or in vivo (single-and multi-unit, evoked potential, or field potential recordings) electrophysiological techniques using intact tissues, spinal cord slices, or primary cultures of sensory neurons is required. The successful candidate will be responsible for the development and implementation of such models to validate and prioritize potential drug candidates and characterize the mechanism of compound action to help drive our pre-clinical pain drug discovery programs. Key Accountabilities: Actively design, perform and interpret experimental studies to help prioritize and characterize the pharmacological action of potential drug candidates. Develop and implement disease relevant in vitro, ex vivo, or in vivo cellular models of pain to elucidate the pharmacological action of ion channel modulators. Demonstrate strong laboratory and scientific leadership. Be able to challenge assumptions and interpretations of data and provide scientific and technical input to project teams Work and interact effectively within a multidisciplinary team of scientists to achieve goals and objectives in a timely manner. Experience: PhD in neuroscience or related field with a minimum of 4 years of postdoctoral experience. Demonstrated technical experience in the preparation of spinal cord slices or dissociated neuronal cell cultures. Broad experience in the use of in vitro or in vivo electrophysiological techniques to study ion channel function and membrane excitability. Laboratory experience of pain pharmacology gained in either the pharmaceutical industry or academia. Excellent oral and written presentation skills. Fredrick Van Goor, Ph.D. Research Fellow I Vertex Pharmaceuticals San Diego, CA, 92121 (858) 404-6642 *** Posted by: Dr. Stanko Stojilkovic *** |
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Tenured or Tenure-Track Investigator job search, Clinical Center & NINDS |
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Tenured or Tenure-Track Investigator Clinical Center & NINDS (deadline: open-ended) The Division of Intramural Research of the National Institute of Neurological Disorders and Stroke and the Radiology and Imaging Sciences Program of the Clinical Center are recruiting an individual for a tenure-track/tenure eligible position in the area of neuroimaging with a focus on clinical research in multiple sclerosis. The individual will develop and direct an independent research program on imaging diseases of the nervous system and especially multiple sclerosis. The program will conduct its work in conjunction with the Neuroimmunology Branch (NIB), which was established to study the cause and treatment of immunological mediated diseases of the central nervous system. The successful candidate will be able to develop strong interactions with an active neuroradiology program and an active neuroimaging program at the NIH. The individual should have a demonstrated background and knowledge in research focused on neuroimaging diseases of the nervous system. In addition to imaging expertise, the individual should have experience in neurology and/or radiology and the application of clinical trial methodology to the study of disease mechanisms and testing new therapies. The candidate will have earned a M.D. or Ph.D. degree and will have excellent scientific skills in structuring an original and productive research program using outstanding communication and collaborative abilities. Preference will be given to individuals who have a medical license in the United States, who have completed training in an accredited training program in radiology or neurology, and is either board eligible or board certified in one of these disciplines. In rare cases outstanding senior candidates will be considered for a tenured position if there is a demonstrated international reputation and well-documented evidence of ongoing independent accomplishments. An individual selected for a tenure-track position is expected to build a dynamic and productive research group. Laboratory facilities, state-of-the-art neuroimaging facilities, research funds and salary are competitive with premier academic institutions. Applicants should send curriculum vitae, bibliography, statement of research interests, and have three letters of reference sent to: Alan Koretsky, Ph.D., c/o Peggy Rollins; Office of the Scientific Director, Division of Intramural Research; National Institute of Neurological Disorders and Stroke, NIH; Building 35 Room GA908; Bethesda, MD 20892; or to Peggy.Rollins@nih.gov. Applications will be reviewed upon receipt. HHS and NIH are Equal Opportunity Employers. ### Link to Fellowships, Staff Scientist and Tenured/Tenure-Track Research Positions http://www.training.nih.gov/ Link to NIH Jobs http://www.jobs.nih.gov/ Deputy Director for Intramural Research Webboard Job site (NIH Access Only) http://www.nih.gov/ddir/Jobs.html *** communicated by Roland A. Owens |
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Tenured or Tenure-Track Investigator, Clinical Center & NINDS |
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Tenured or Tenure-Track Investigator Clinical Center & NINDS (deadline: open-ended) The Division of Intramural Research of the National Institute of Neurological Disorders and Stroke and the Radiology and Imaging Sciences Program of the Clinical Center are recruiting an individual for a tenure-track/tenure eligible position in the area of neuroimaging with a focus on clinical research in multiple sclerosis. The individual will develop and direct an independent research program on imaging diseases of the nervous system and especially multiple sclerosis. The program will conduct its work in conjunction with the Neuroimmunology Branch (NIB), which was established to study the cause and treatment of immunological mediated diseases of the central nervous system. The successful candidate will be able to develop strong interactions with an active neuroradiology program and an active neuroimaging program at the NIH. The individual should have a demonstrated background and knowledge in research focused on neuroimaging diseases of the nervous system. In addition to imaging expertise, the individual should have experience in neurology and/or radiology and the application of clinical trial methodology to the study of disease mechanisms and testing new therapies. The candidate will have earned a M.D. or Ph.D. degree and will have excellent scientific skills in structuring an original and productive research program using outstanding communication and collaborative abilities. Preference will be given to individuals who have a medical license in the United States, who have completed training in an accredited training program in radiology or neurology, and is either board eligible or board certified in one of these disciplines. In rare cases outstanding senior candidates will be considered for a tenured position if there is a demonstrated international reputation and well-documented evidence of ongoing independent accomplishments. An individual selected for a tenure-track position is expected to build a dynamic and productive research group. Laboratory facilities, state-of-the-art neuroimaging facilities, research funds and salary are competitive with premier academic institutions. Applicants should send curriculum vitae, bibliography, statement of research interests, and have three letters of reference sent to: Alan Koretsky, Ph.D., c/o Peggy Rollins; Office of the Scientific Director, Division of Intramural Research; National Institute of Neurological Disorders and Stroke, NIH; Building 35 Room GA908; Bethesda, MD 20892; or to Peggy.Rollins@nih.gov. Applications will be reviewed upon receipt. HHS and NIH are Equal Opportunity Employers. |
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