Miscellaneous

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Announcements
		A Tribute To Masaru Yamaizumi M.D., Ph.D. 1945-2006
		Masaru Yamaizumi passed away on May 9, 2006. He graduated from Kyoto University Medical School in 1970, and as a graduate student of Osaka University, he joined Prof. Yoshio Okada's laboratory. Prof Okada is a discoverer of Sendai Virus-mediated Cell Fusion. I also joined Okada's group in 1973 as a graduate student. Although Masaru and I studied together for 4 years in Okada's laboratory, we have never overlapped each other with respect to the working time in the lab. When I entered the lab in the morning, I frequently saw Masaru sleeping in his "Schlaf" (Sack). He used to start his experiments after supper and work overnight. He woke up at noon, and in the afternoon he used to play tennis with other students in the Institute. He began playing tennis in Osaka and quickly improved his skill hence and became a top player among the students. However, I should say that he was also a top runner among the students in the research. Once he became interested in something, he always strongly devoted himself to it. He was so skillful in the experiments and nobody could mimic his delicate techniques. During his stay in Okada's laboratory, he developed several sophisticated methods such as red blood cell-ghost fusion to introduce the macromolecules into living mammalian cells. One of his representative works using these methods was the finding that the cell was killed by one molecule of diphtheria toxin fragment A. After his postdoctoral fellowship in Dr. Frank Ruddle's laboratory in Yale, he became interested in micro-needle injection. He adopted this technique to purify the factor that is missing in XP-A cells. In 1987, he was promoted as Professor in Kumamoto University Medical School, where he finally succeeded in purifying a XPA factor. In Kumamoto, he identified a UV-sensitive syndrome, and discovered human homolog of RAD18 that turned out to be a major player of translesion DNA synthesis. He was a quiet person, yet he has had lots of dreams during his lifetime. He was only 60 years old when he died. His memorial symposium was held in Kumamoto University on July 21, 2006 and hundred of people including Prof. Okada gathered in this Symposium. We wished for his research to develop and continue even after he is no longer with us. - Kiyoji Tanaka M.D., Ph.D. Human Cell Biology Group Laboratories for Organismal Biosystems Graduate School of Frontier Biosciences Osaka University e-mail: ktanaka@fbs.osaka-u.ac.jp Posted 7-2006

		Deaths - Anthony Dipple, D.Sc., Ph.D. 1940 -1999
		It is with great sadness that we inform the DNA repair community of the sudden passing of our colleague, Dr. Anthony Dipple, on May 26, 1999. Dr. Dipple was born in 1940 in Mansfield, England and received his Ph.D. in biological chemistry from the University of Birmingham in 1964. He then accepted a research fellowship with the late Charles Heidelberger at the McArdle Laboratory, University of Wisconsin. In 1966, at the Institute for Cancer Research in London he began what would be his life's work: research on polycyclic aromatic hydrocarbon interactions with DNA. There, with Philip Lawley and Peter Brooks he worked toward establishing the importance of metabolic activation in the action of these carcinogens and elucidating the nature of the bonding of these compounds to DNA. In 1975, Dr. Dipple moved to the newly created cancer research labs in Frederick, MD to further his research into the molecular mechanisms involved in chemical carcinogenesis. Dr. Dipple was a world authority on the basic chemistry of DNA alkylation and aralkylation. His lab was responsible for extensive spectroscopic characterizations of hydrocarbon-DNA adducts. Dr. Dipple and his colleagues have studied the mutagenic properties of the hydrocarbon-DNA adducts both in vitro and in vivo. Recently, his lab was investigating the effect of hydrocarbon-DNA adduct formation on the cell cycle. Major colleagues of Dr. Dipple have included C. Anita Bigger, Robert C. Moshel, William M. Baird, Ronald G. Harvey, Shantu Amin, Karen Vousden and Donald M. Jerina. Dr. Dipple has authored 164 papers, given 60 invited lectures, contributed to some 40 symposia, served on 20 review committees, and mentored countless post-docs through his lab in Frederick. In 1980, along with Dr. R.C. Garner he established the journal Carcinogenesis and served as an executive editor until his death. He was co-editor of a IARC Monograph on DNA adducts, an editorial board member for both Chemical Research in Toxicology, and Women and Cancer, and served as a reviewer of manuscripts for 11 other journals. In recognition of his life's accomplishments he was awarded a Doctor of Science degree from the University of Birmingham in 1987. Dr. Dipple will be missed by the scientific community worldwide for his great scientific contributions. All those who worked with him will miss his patience as a teacher, and the goodwill and support he gave to all. - Karen Canella, Ph.D. Posted 5/31/99

		Deaths - Erling Christen Seeberg (1946-2004)
		We are saddened to inform you that Dr. Erling Seeberg passed away on December 14, 2004. He bravely fought his illness for years and until recently he was very active in work and leisure. Erling was one of the giants in DNA repair. His lab made critical discoveries in base excision repair and other areas of DNA repair. From his early work on UVR ABC protein to his recent work on RNA repair, his group consistently came up with seminal work. Erling grew up in Norway and spent his career there aside from some time at Yale in the 1970's and in Strasbourg, France in the 1990's. He received his PhD in 1980 and has been a full professor at Oslo University since 1987. Erling participated in numerous scientific meetings. He was noted for his excellent talks, his engaging discussions and his enlightening suggestions. He had a profound understanding of the topics that he worked on and had excellent insights into the mechanisms involved. Many of us will remember that aspect but also recall his great sense of humor and his ability to give unscheduled speeches. Above all we appreciate his positive influence on his surroundings. There are many wonderful stories about Erling. He was truly someone who was able to relish many facets of life and who pursued many interests. His numerous friends and colleagues worldwide will truly miss him and cherish their memories of him. - Vilhelm Bohr ----------------------------------------------------------------- Posted 9-2-2005

		Deaths - Dale W. Mosbaugh, Ph.D. September 2, 1953 – February 17, 2004
		Dale W. Mosbaugh, Ph.D., 1953-2004 We are deeply saddened to inform the Research Community of the sudden death of Dr. Dale W. Mosbaugh on February 17, 2004. Dale was born in Cincinnati, Ohio, where he also grew up. He attended the University of Cincinnati, receiving his baccalaureate in 1975. He continued at the University of Cincinnati as a graduate research assistant in the laboratory of Dr. Ralph Meyer and earned his doctorate in 1979. During his studies with Dr. Meyer, Dale began his life long interest in the enzymology of DNA repair, publishing work on DNA polymerase beta and its interaction with DNase V. Also working in the Meyer Lab at that time was a graduate student who became a life long close friend with Dale, Tom Kunkel. From Cincinnati, Dale moved to UC Berkeley, where he was a NIH postdoctoral fellow in Dr. Stu Linn’s laboratory from 1979-1983. At Berkeley, Dale conducted extensive biochemical studies on AP endonucleases. In 1980, Dale demonstrated that AP endonuclease isolated from HeLa cells could be divided into two classes. Class I AP endonuclease cleaved on the 3’ side of the AP site, producing 3’-deoxyribose- and 5’-phosphomonoester termini; whereas class II AP endonuclease cleaved on the 5’ side of the AP site, producing 3’-hydroxyl nucleotide and 5’-deoxyribose phosphate termini. Only DNA substrates incised by a class II AP-endonuclease could support DNA synthesis. The class I AP endonuclease is now better known as the AP lyase. In 1984, almost twenty years ago, Dale demonstrated complete small gap-filling by HeLa DNA polymerase beta. Dale and Dr. Linn continued their close association until Dale’s death. Following his postdoctoral studies, Dale accepted a position as Assistant Professor at the University of Texas at Austin, where he taught and conducted research until 1989. At UT-Austin, Dale focused his research on biochemical studies of nuclear and mitochondrial uracil-DNA glycosylase, cloning of the PBS2 uracil-DNA glycosylase inhibitor gene (ugi), biochemical studies of the Ugi protein, and biochemical studies of porcine DNA polymerase gamma. These studies were continued at Oregon State University in 1989. There, the Mosbaugh laboratory perfected the Activity Gel technique for characterizing DNA metabolizing enzymes. Dale’s other studies at OSU included the fidelity of uracil-initiated repair in human and bacterial cell extracts, the molecular mechanism of Ugi inhibition of uracil-DNA glycosylase, and the structure of the Ugi protein. In 1995, Dale, John Tainer, and their colleagues reported a novel type of protein structure inferred from studies of the Ung•Ugi complex: protein mimicry of DNA. Dale believed strongly in the scientific endeavor as a community of scholars, and he gave his time selflessly in support of that community. He served for nearly two decades as a grant proposal and program project reviewer. When the Oregon State University Environmental Health Sciences Center lost its director to illness, Dale served as Interim Director and led the effort to a successful renewal of the Center grant. Those who worked with Dale appreciated his qualities of good humor, patience, respect for others, attention to detail, and energetic dedication to science. Dale’s life and career greatly influenced many lives. He is dearly and sorely missed. Sincerely, Zhigang Wang, Matt Longley, Samuel Bennett, Russ Sanderson, Jung-Suk Sung, and Cheng-Yao Chen In memory of Dale W. Mosbaugh, a scholarship fund has been set up for a deserving athlete from one of the three local high schools in the Corvallis area where Dale was highly active. Donations may be made to: Citizens Bank The Dale W. Mosbaugh Scholarship Fund P.O. Box 30 Corvallis, OR 97339 ________________________________________________________________________________ Posted 3-8-2004

		Deaths - DAVID B. BUSCH, Ph.D., M.D. 1953-2002
		DAVID B. BUSCH, Ph.D., M.D. July 25, 1953 - April 11, 2002 It is with great sadness that we announce the passing of our friend and colleague, Dr. David B. Busch who succumbed to leukemia on April 11 at the age of 48 years. David was a remarkable, intelligent, and dedicated person. He received an undergraduate degree in biochemistry with distinction in 1974, a masters in biophysics in 1976 and Ph.D. in biophysics in 1980 all at the University of California, Berkeley. His Ph.D. work was performed under the guidance of Nobel prize winner, Dr. Donald Glaser. He then earned an M.D. degree in 1982 in a special 2 year program for Ph.D's at the University of Miami. This was followed by residencies in anatomic and clinical pathology at the University of Wisconsin in Madison which culminated in his becoming a Diplomate of the American Board of Pathology in 1986. The same year he joined the Armed Forces Institute of Pathology in Washington, DC where he spent his professional career as a Radiation Pathologist. His early DNA repair work was focused at discovering DNA repair mutants in Chinese hamster cells. He performed large scale isolation and characterization of UV sensitive DNA repair mutants of these CHO cells. This work led to the discovery of rodent cells that were homologues of several human diseases: xeroderma pigmentosum (XP) complementation group D (ERCC2), group B (ERCC3), group F (ERCC4), group G (ERCC5), Cockayne syndrome group B (ERCC6) and Fanconi anemia group G (UV40). Each of these cell lines was pivotal in the efforts by several laboratories to clone the corresponding these human genes. Over the last 25 years David had an extremely successful interaction with Dr. Larry Thompson at Lawrence Livermore National Laboratory. Although Larry was not a formal member of David's Ph.D. thesis committee, Larry provided David with guidance and considered him to be a truly outstanding graduate student. David always seemed to understand everything and was able to set high goals for himself and meet them. David ensured that mutants were still being sent to Livermore by technicians after he had gone to medical school. When the Glaser laboratory closed because of loss of funding, Larry maintained David's mutant collection in liquid nitrogen for about a decade until David established his own laboratory in Washington, DC. David then systematically analyzed the complete collection and produced a series of publications that involved collaborations with scientists in the Netherlands, in Texas, and other places. This extended accomplishment was a reflection of David's thorough, persistent research style. Larry's lab benefitted immensely from David's mutants. Some of the mutant lines have been in a national repository for many years and will continue to serve numerous investigators indefinitely. When Dr. Kenneth Kraemer first met David, Dr. James Cleaver had been performing clinical diagnostic tests for XP patients in the US. New Federal regulations made it difficult for Jim to continue this work in a research lab. David, who was a card-carrying pathologist in a distinguished institution that was familiar with Federal regulations, stepped in to perform this valuable service. David put his heart and soul into this important work. He began by offering testing for XP and then expanded to test for Cockayne syndrome and trichothiodystrophy. He tested samples from several hundred patients over the years. These results have changed many people's lives. The Kraemer laboratory and others around the world are currently performing further analysis on many of these cells and will be studying them for years to come. The laboratory work was only part of his effort. David soon realized that the people whose cells he tested were searching for assistance as well. He regularly visited Camp Sundown, a camp for XP patients, and a similar group for families with Cockayne Syndrome. He brought his cats and his good humor to cheer up those affected with XP and CS. He will be greatly missed. Sincerely, Kenneth H. Kraemer, M.D., Bethesda, MD James E. Cleaver, Ph.D., San Francisco, CA Larry H. Thompson, Ph.D., Livermore, CA ------------------------------------------------------------------- Cards and letters can be sent to his mother: Mrs. Barbara Busch, 10 Heather Ave, San Francisco, CA 94118 JSB94118@aol.com The family requested that donations in David Busch's memory can be made to: "The XP Society" The XP society also has a tribute to Dr. Busch on their website. "The Share and Care Cockayne Syndrome network" or the "memorial scholarship fund for David Busch" at the San Francisco Hebrew Free Loan Association ------------------------------------------------------------------- Of additional interest: David Busch maintained a website "Myelodysplasia and me" that chronicled the unfortunately rapid course of his disease beginning from diagnosis as a precancer in November 2000 David was fond of exotic cats as can be seen in his other website: "About Jadzia Cattery and Emony's Exotic Cats" which describe his efforts to breed exotic Norwegian forest cats and Canadian lynxes David Busch prepared an educational CD "Xeroderma Pigmentosum and Cockayne Syndrome - A Multimedia Overview" which includes video clips of patients and researchers . He also made two educational videotapes: "Cockayne Syndrome (CS) and Xeroderma Pigmentosum (XP)" and "DNA Repair Disorder: X-Ray Sensitivity Disorder/Administrative and Regulatory Issues in Laboratory Diagnosis of DNA Repair Deficient Patients". These may be purchased through "the online catalogue of the Armed Forces Institute of Pathology" . Look in the "Study sets" heading. ________________________________________________________________________ Posted 9/05/2002

		DEATHS- A TRIBUTE TO LARRY GROSSMAN Ph.D. 1924 – 2006
		Lawrence (Larry) Grossman passed away on January 13, 2006, and with him we lost one of the great pioneers and leaders in the field of DNA repair. Larry was a fighter pilot during WWII and his plane was shot down over the Pacific. He was saved after two days alone on a small raft in the ocean. After the war he studied biochemistry and became a professor at Brandeis University, and later department chair at Johns Hopkins University at the School of Public Health, now called the Bloomberg School. He developed an outstanding department and recruited many leading scientists in the general area of biochemistry of DNA metabolism. Larry's own research focused on two areas. The first was pioneering work in understanding excision repair in bacterial systems. He clarified the biochemical properties and function of the components of the UVr ABC excinuclease. Later in his career he pioneered population studies on DNA repair. He developed methods to measure DNA repair in blood samples from large numbers of subjects. He then trained and collaborated with epidemiologists to correlate DNA repair capacity with risk of cancers in large populations. It is rare that a scientist masters these diverse areas of biochemistry and epidemiology and is able to make important contributions to both. Larry trained many students and postdoctoral fellows and there is a great devotion to him amongst them. This is because of Larry's magnetic personality, great care and interest for others and his wonderful sense of humor. He loved to tell stories and wouldn't hesitate to make fun of himself as well. Classic is his joke: "When I gave a lecture at a University, I started by asking the audience if everyone could hear me. From the back row someone raised their hand and said: Yes, I can hear you, Dr. Grossman, but I would be glad to switch places with someone who can’t." Larry was born in 1924 and lived a full life. He and his lovely wife Barbara (Bobbie) traveled to many meetings all around the world. More recently they spent the summers at their house in Woods Hole, MA, where they had many friends and Larry would participate in scientific seminars and discussions. Dr. Larry Grossman gave a videoconference talk to the DNA Repair Interest Group on Tuesday, May 25, 1999. The talk was on the history of DNA Repair titled "Four decades of DNA Repair: From populations of molecules to populations of people.". The video is archived on "videocast-DNA Repair Interest Group Sessions" website. A tribute to Larry can also be viewed at "Tribute to Larry Grossman" Vilhelm A. Bohr, Mohammad Hedayati and Kenneth H. Kraemer _________________________________________________________ LAWRENCE GROSSMAN MEMORIAL GATHERING To honor Larry Grossman's life as a scientist and as a special human being, the Department of Biochemistry and Molecular Biology held a memorial for him on February 21, 2006, in the Bloomberg School of Public Health. If you would like to make a gift in honor of Larry Grossman, his family has requested that any donations be directed to the Lawrence Grossman Lectureship. It is our hope that this endowed lecture fund will support an annual lecture by a prominent researcher working in the area of DNA repair, providing an opportunity to remind future generations of Larry's inspirational personal qualities as well as his enormous contributions to the research field he helped found. Donations by check made out to JHU can be mailed to: Ms. Yolanda Tillett, Development and Alumni Affairs Johns Hopkins Bloomberg School of Public Health 615 North Wolfe Street, W1600 Baltimore, MD 21205 For more information contact: Dr. Les Hanakahi Johns Hopkins University Bloomberg School of Public Health Department of Biochemistry and Molecular Biology 615 North Wolfe Street Baltimore, MD 21205 email: lhanakah@jhsph.edu; Tel: (1+) 443-287-2515 (office)

		DNA Repair Group Meetings
		A listing of all previous DNA Repair meetings from 1995 through 1998.


Job Notices
		HUMAN DISEASES WITH DEFECTIVE DNA REPAIR - POST-DOCTORAL FELLOWSHIP - BETHESDA, MD
		We are studying molecular, cellular and clinical abnormalities in patients with defective DNA repair and possible links of these genes to disease in the general population. Current emphasis is on xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy. A postdoctoral position is available for a talented individual (M.D., Ph.D. or MD-PhD) with less than 5 years of postdoctoral experience who has knowledge of molecular biology and DNA repair. Representative publications: Emmert, S., Kobayashi, N., Khan, S. G. and Kraemer, K. H.: The Xeroderma Pigmentosum Group C Gene Leads To Selective Repair Of Cyclobutane Pyrimidine Dimers Rather Than 6-4 Photoproducts. Proc. Natl. Acad. Sci. USA 97: 2151-2156, 2000. Emmert, S., Schneider, T.D., Khan, S.G. and Kraemer, K.H.: The human XPG gene: gene architecture, alternative splicing and single nucleotide polymorphisms. Nucleic Acids Research, 29:1443-1452, 2001 Emmert, S., Slor, H., Busch, D.B., Batko, S., Albert, R.B., Coleman, D., Khan, S.G., Abu-Libdeh, B., DiGiovanna, J.J., Cunningham, B.B., Lee, M-M, Crollick, J., Inui, H., Ueda, T., Hedayati, M., Grossman, L., Shahlavi, T., Cleaver, J.E. and Kraemer, K.H.: Relationship of neurologic degeneration to genotype in three xeroderma pigmentosum group G patients. J. Invest. Dermatol. 118:972-982, 2002 Takeuchi, S., Zhang,W., Wakamatsu, K., Ito S., Hearing,V.J., Kraemer, K.H. and Brash, D.E.: Melanin acts as a potent UVB photosensitizer to cause a novel mode of cell death in murine skin. Proc. National Acad.Sci USA 101:15076-81, 2004. Khan, S.G., Oh, K-S, Shahlavi, T., Ueda, T., Busch, D.B., Inui, H., Emmert, S., Imoto, K., Muniz-Medina, V., Baker, C.C., DiGiovanna, J.J., Schmidt, D., Khadavi, A., Metin, A., Gozukara, E., Slor, H., Sarasin, A. and Kraemer, K.H: Reduced XPC mRNA levels in clinically normal parents of xeroderma pigmentosum patients. Carcinogenesis 27: 84-94, 2006. Christine Liang, Andrea Morris, Sebastian Schlücker, Kyoko Imoto, Vera Price, Emory Menefee, Stephen M Wincovitch, Ira Levin, Deborah Tamura, Katrin Strehle, Kenneth H. Kraemer and John J. DiGiovanna: Structural and molecular hair abnormalities in trichothiodystrophy. Journal of Investigative Dermatology 126: 2210-2216, 2006. Kyu-Seon Oh, Sikandar G. Khan, N.G.J. Jaspers , Anja Raams, Takahiro Ueda, Alan Lehmann, Peter S. Friedmann, Steffen Emmert, Alexi Gratchev, Katherine Lachlan, Anneke Lucassan, Carl C. Baker, Kenneth H. Kraemer: Phenotypic heterogeneity in the XPB DNA helicase gene: Xeroderma pigmentosum without and with Cockayne syndrome. Human Mutation 27: 1092-1103, 2006. To apply, send CV and bibliography and names (with contact information) of 3 references to: Kenneth H. Kraemer, M.D. Chief, DNA Repair Section,Basic Research Laboratory Center for Cancer Research, National Cancer Institute Building 37 Room 4002 MSC 4258 Bethesda, MD 20892 -4258 301-496-9033 FAX: 301-594-3409 e-mail: kraemerk@nih.gov DNA Repair Interest Group web site: http://www.nih.gov:80/sigs/dna-rep/ Kraemer Lab web site: http://ccr.cancer.gov/staff/staff.asp?profileid=5592 NIH is an equal opportunity employer. Posted Jan 2, 2007

Archives
		DNA REPAIR Journal
		The DNA Repair section of Mutation Research is now changed into a new journal, completely separate from Mutation Research. The new web site explains the new journal: http://www.elsevier.com/locate/dnarepair Posted 12/9/2001
		DNA Repair Listserve Archives
		Back isssues of DNA Repair Interest Group e-mail updates
		Mutation Research Forum
		This Elsevier website is billed as "The online newsletter for the mutation research community". It lists news, book reviews, abstracts of Mutation Research articles and other items. Posted 11/15/2000

Databases
		Biocompare
		This website www.biocompare.com calls itself “The Buyer’s Guide for Life Scientists” This site includes comparisons of many reagents that are useful for DNA repair studies including a listing of antibodies. Posted 1/14/2004
		CHEMICALLY INDUCED MOUSE MUTANTS AVAILABLE
		The McLaughlin Research Institute is in the first year of a mouse chemical mutagenesis program and has mutants available for non-commercial research purposes. Although our web site is still under construction, details can be found by going to our site http://www.montana.edu/wwwmri/ and following the "resources" link to "mutagenesis program" or by going directly to: http://www.montana.edu/wwwmri/enump.html Suggestions for other lists that might have members who would be interested are welcome. George A. Carlson (gac@po.mri.montana.edu) Director McLaughlin Research Institute 1520 23rd Street South Great Falls, Montana 59405 406 454 6044, fax: 454 6019 or 454 6004 Revised 8/99
		CORIELL CELL REPOSITORIES
		This site provides access to several resources that provide cells and DNA for scientific study. It contains the Human Genetic Mutant Cell Repository (funded by NIGMS), the Aging Cell Repository (funded by NIA) and several others. Revised 5/5/99
		DNA Repair Gene SNP Websites
		The Environmental Genome project http://www.niehs.nih.gov/envgenom/home.htm of NIEHS has resequenced many genes from 90 donors. As part of this project a website run by the Univ of Utah has a list of SNP's in 96 human DNA repair genes: http://www.genome.utah.edu/genesnps/cgi-bin/query.cgi?FunctionClass=DNA_Repair Posted 1/21/2003
		DNA Repair Genes in the Human Genome
		The compilation of human DNA repair genes is in the Feb. 16, 2001 issue of Science (291, pp. 1284-1289). This article can be accessed online. http://www.sciencemag.org/cgi/content/abstract/291/5507/1284 An online Table with links to Gene Cards and NCBI gives ready access to a huge amount of information on 127 DNA repair and related genes and their protein products. The most recent version of the table is available at: http://www.cgal.icnet.uk/DNA_Repair_Genes.html Posted 2/13/2001 Revised 5/29/2002
		HUMAN DIVERSITY-ORIENTED DNA REPOSITORY
		I hope that you and your colleagues will be interested in our human diversity-oriented DNA repository, a unique resource for the study of human DNA polymorphism. The National Laboratory for the Genetics of Israeli Populations at Tel-Aviv University has a unique DNA collection representing the large ethnic variation of Israeli populations. We have in our repository nearly 2000 DNA samples and cell lines from healthy unrelated individuals. Our sample donors include unrelated representatives of European, Asian, African and Middle-Eastern communities. We already distributed over 6500 DNA samples to reserchers in the USA, Canada, Europe, Australia, Japan, India and Israel. Individuals who donated blood samples for the preparation of the human cell lines and the DNA collection have signed written consent for the study of their genome for pure and applied research purposes. The coded DNA samples are kept with strict confidentiality; only sex and ethnic background are supplied along with the DNA samples. For more information kindly visit our web site: http://www.tau.ac.il/medicine/NLGIP/nlgip.htm Details on prices and sample availability are at: http://www.tau.ac.il/medicine/NLGIP/catalog.htm I shall be happy to answer specific questions on sample availability. Sincerely, David Gurwitz, Ph.D. National Laboratory for the Genetics of Israeli Populations Room 306 Sackler Faculty of Medicine Tel-Aviv University Tel-Aviv 69978, ISRAEL voice/fax: +972-3-640-7611 e-mail: gurwitz@post.tau.ac.il http://www.tau.ac.il/medicine/NLGIP/nlgip.htm Posted 3/27/2001
		MEDLINE ALERT TOOL
		Dr. Dmitry Mozzherin, Ph.D. writes: I am a member of Pharmacology Dept, SUNY Stony Brook, and one of the participants of the Repair group. Recently I wrote a web-based program, which periodically supplies its subscribers with references to new articles from Medline. This program is free and released under GPL lisence. It can be used with a web-browser (it is running at Stony Brook), or people can download it and use it locally. Homepage: http://phm-pf-3.pharm.sunysb.edu/biomail The program: http://phm-pf-3.pharm.sunysb.edu/cgi-bin/biomail/users.pl People in our department like it and I think this progam would be very useful for the rest of the "Repair world". Revised 11/15/2000
		ON-LINE VERSION OF THE DNA REPAIR MOUSE MUTANT DATABASE
		Version V of the DNA repair mouse mutant database maintained at University of Texas Southwestern Medical School is now up and running at http://pathcuric1.swmed.edu/Research/research.htm "Mouse DNA Repair Database" Revised 2/2003
		PARP Link
		The PARP Link is a database of information pertaining to the poly (ADP-ribose) polymerases (PARP) family of proteins and to their role in maintaining the integrity of the eukaryotic genome. Revised 8/21/2008
		PUBMED
		The National Library of Medicine has a FREE website permitting search of more than 9 million citations as well as GenBank DNA and Protein sequences. The location is http://www.ncbi.nlm.nih.gov/PubMed/ Posted 2/14/2000
		XERODERMA PIGMENTOSUM AND COCKAYNE SYNDROME HUMAN MUTATION DATABASE WEBSITE
		A new web-site is now open listing most currently known mutations in the xeroderma pigmentosum and Cockayne syndrome genes. This contains brief summaries of DNA repair, the individual genes, a map of mutations, and a searchable database for each mutation and cell line in the open literature. It contains a mechanism for posting comments and corrections for the author, James E. Cleaver, and will be updated and corrected as new information is available. See this at http://xpmutations.org Posted 4/8/2002

Groups
		ABCAM LTD.
		Abcam Ltd ( www.abcam.com ) - At present, we have a fairly substantial range of products including those relating to DNA damage and repair (246 in total), and are actively developing this as we speak. Please find a hyperlink provided below for your review. http://www.abcam.com/index.html?pageconfig=catalog_byclass&intClassID=6 Thank you in advance for your time and kind consideration. Miss Lesa Rodgers Marketing Assistant Abcam Ltd 21 Cambridge Science Park Milton Road, Cambridge, Cambridgeshire CB4 0TP United Kingdom www.abcam.com Posted 11/29/2003
		Astral Biologicals, Inc, San Ramon, CA.
		Antibodies for research applications. Please visit our web site: http://www.australbio.com posted 1/08/2003
		BBC Horizon show in Xeroderma Pigmentosum
		Link to British Broadcasting Company Horizon TV program on Xeroderma Pigmentosum http://www.bbc.co.uk/horizon/moonchild.shtml This program "Moon Children" aired on April 4, 2000. The website presents highlights of the material with transcripts of interviews with XP families and discussion of diagnostic problems.
		Bethyl Laboratories, Inc.
		Antibodies for DNA Damage/Repair and related research. New antibodies include RhoB, Fen1, H2AX gamma, NF1, p73, USP7, RFC2, RFC4, RFC5, p14ARF, SA-1, SA-2 and RPA32. See www.bethyl.com for new antibodies contiually being added.
		Chemically Induced Mouse Mutants
		The McLaughlin Research Institute is in the first year of a mouse chemical mutagenesis program and has mutants available for non-commercial research purposes. Although our web site is still under construction, details can be found by going to our site http://www.montana.edu/wwwmcb/mclaugh.html and following the "resources" link to "mutagenesis program" or by going directly to: http://www.montana.edu/wwwmcb/enump.html Contact for more information: George A. Carlson (gac@po.mri.montana.edu) Director McLaughlin Research Institute 1520 23rd Street South Great Falls, Montana 59405 TEL: 406 454 6044, FAX: 454 6019 or 454 6004 Posted 7/28/99
		Chemistry/Biochemistry Jobs Vacancy website
		Emedia Science Ltd in association with Liverpool University, UK would like to announce a new chemistry jobs vacancy site at http://www.chemjobs.net . The site already lists over 200 vacancies for chemists. We invite you to submit vacancies for academic / commercial posts, post-doctoral fellowships and PhD studentships free of charge. Register for a weekly e-mail bulletin of new vacancies and get a chance to win a copy of Chemdraw Pro worth 900 US dollars. Paul Heelis, B.Sc., Ph.D Emedia Science Ltd PO Box 92 New Ferry CH63 9WA Tel: 0151 647 0008 Fax: 0151 647 0047 e-mail: paul@emedia-science.co.uk http://www.emedia-science.co.uk posted 1/14/00
		CHILDREN OF THE MOON
		This web site is dedicated to providing interesting information about and activities for famililes with xeroderma pigmentosum and other photosensitive disorders - especially children. The site is constantly changing with new and timely material. http://www.moonchildren.com/welcome.html Posted 9/23/99
		Comet Assay Interest Group
		Single cell gel (SCG) electrophoresis or 'Comet assay' is a rapid and very sensitive fluorescent microscopic method to examine DNA damage and repair at individual cell level. This international website provides information about the assay, protocols, and a NIH listserve for discussion of the assay. Posted 11/18/2001
		DNA DAMAGE AND REPAIR PRODUCTS
		The inherent chemical instability of DNA renders it vulnerable to damage by both endogenous and exogenous agents. As such, cells have DNA repair processes to counteract the deleterious effects of DNA damage and to maintain genomic integrity. Among these repair processes are direct repair, base excision repair (BER), nucleotide excision repair (NER), mismatch repair, and double strand break repair. All of these mechanisms work in concert with the cell cycle and programmed cell death to maintain genomic fidelity and integrity for the organism. R&D Systems now offers a variety of products for use in DNA Damage and Repair studies. For information on these or other product lines, please call 1-800-343-7475 or visit our web site at http://www.RnDSystems.com Posted 1/17/2002
		Enzymax, Lexington, KY
		Good news to the DNA repair community! Many DNA repair enzymes and proteins are now available from Enzymax (www.enzymax.net). Purified proteins include Y family DNA polymerases, various DNA glycosylases, AP endonucleases, PCNA, Ku70, Ku80, p53, etc. Molecular reagents, PCR reagents, and custom DNA construction and protein purification are also available. Enzymax, maximizing your research productivity! Xiaohua (Michelle) Wu Enzymax LLC TEL: (859) 257-2300 ext. 280 www.enzymax.net Posted 1/16/2003
		Genetex
		Located in Texas they have lisings for DNA repair antibodies. Posted 1/14/2004
		MBL International
		MBL International offers many kits and reagents for research on DNA Damage and Repair. MBL is especially excited to introduce two unique monoclonal antibodies that can detect the major classes of UV-induced photolesions: Cyclobutane Pyrimidine Dimers (CPD) or pyrimidine-[6-4]-pyrimidinone photoproducts (6-4 PP). These antibodies were established by Dr. T. Mori et al.in Japan. For more information on these antibodies, please visit the following links http://www.mblintl.com/mbli/catalog/pdf/d195-1.pdf (anti-6-4PP) http://www.mblintl.com/mbli/catalog/pdf/d194-1.pdf (anti-CPD) or contact Conrad Maher Key Account Manager MBL International 800-200-5459 conrad@mblintl.com www.mblintl.com
		Novus Biologicals, Inc., Littleton, CO
		Antibodies for DNA Repair Research (http://www.novus-biologicals.com/research.php/8) and other research applications (www.novusbio.com). New antibodies include FANCD2, XRCC(2&3), RAD51(B,C,&D), Tankyrase, DMC-1, DNA polymerase iota, and PAK6. Posted 1/19/2003
		Operon Biotechnologies
		Operon is asking researchers who are interesting in CPD oligos cis-syn thymine dimers or cissyn cyclobutane pyrimidine dimers (CPDs) to contact us. We are looking to make these modified oligos available and are extremely interested in speaking with you about your specific requirements. Our technology, experience, and capacity are unparalleled in the industry, resulting in unsurpassed quality and service for 20 years. Operon offers custom synthesis of affordable, high-quality oligonucleotides - including a full range of longmers and modified oligos - in a variety of scales, concentrations, formats, and purification levels. Every effort will be made to help in your research efforts. Please contact: Michael Melch Operon Biotechnologies, Inc. Southeast Business Manager Cell: (301) 814-1292 Fax: (251) 252-7753 Email: michael.melch@operon.com or oligo-us@operon.com Posted 1/3/2006
		PharmMingen - DNA Damage and Repair Reagents
		PharmMingen has a new catalogue of DNA Damage and Repair Reagents. These include purified DNA repair enzymes, RNase protection assays, antibodies against altered DNA and antibodies against DNA repair related proteins. Posted 6/7/99
		Photobiology Online
		Photobiology Online is a cooperative presentation of the European and American Societies for Photobiology. It is a central source for links to these organizations and to information about photobiology. There is a mirror site in Europe http://pol.newi.ac.uk/ Posted 6/7/99
		R&D Systems - DNA Damage and Repair Research Reagents
		We now offer substrates, enzymes, antibodies, detection kits, and other reagents for use in DNA damage and repair research endeavors. Please find specific product information at http://www.rndsystems.com Posted 10/30/2002
		Reliable Biopharmaceutical Corporation
		As the leading U.S. manufacturer of modified nucleic acids, we wanted to introduce you to our newest product: cis-syn TpT Cyclobutane Dimer Phosporamidite. Specially developed for the DNA repair and research markets. You can see our homepage and our TpT Dimer Amidite webpage to better understand our company and products. If I or my staff can answer any of your specific questions, please call at your convenience. Sincerely, Sourena Nadji, Ph.D. Reliable Biopharmaceutical Corporation Director of Research and Development (314)429-7700 http://www.reliablebiopharm.com/ Posted 3/31/2003
		SAGE BioVentures, Inc. - Antibodies for research applications.
		Products cover virtually every area of biology including apoptosis, cancer, cardiology, cell cycle/regulation, DNA repair, immune system, infectious diseases, neuroscience, signal transduction and transcription factors. Please visit our web site: http://www.sagebioventures.com to learn more about our many exciting products. Posted 10/30/2002
		Santa Cruz Biotechnology, Inc, Santa Cruz, CA
		Antibodies for research applications. Please find specific product information at http://www.scbt.com Posted 1/08/2003
		SFRI Diagnostics - Damaged DNA Detection kit
		The 3D TEST "Damaged DNA Detection" is a kit manufactured by a SFRI Diagnostics - sfri@sfri.com - to detect and quantify DNA damage (BER, NER,...).Included in the kit, plamid DNA and control, cell-free extracts, labeled nucleotides (dUTP-biotine), luminescent substrat buffers and sensitized microplate . SFRI Diagnostics co-operate with Professor Bernard SALLES, DNA repair team of CNRS Pharmacologie and Structural Biology in Toulouse France. [Salles & al., (1995), Analytical Biochemistry, 232, 37-42].
		The American Society for Cell Biology
		The American Society for Cell Biology was founded in 1961 to bring the varied facets of cell biology together. The Society's objective is to provide for the exchange of scientific knowledge in the area of cell biology. It does so through the scholarly dissemination of research at it Annual Meeting and in its publications, and strives to ensure the future of basic scientific research by providing training and development opportunities for students and young investigators, and also by keeping Congress and the American public informed on the importance of biomedical research. Posted 10/19/2001
		Trevigen - DNA Repair Reagents
		Trevigen is a leading supplier of DNA damage research tools, including CometAssay™ Kits and Slides, FLARE Kits, PARP and PARG products, DNA repair enzymes, antibodies to DNA damage adducts, and antibodies for oxidative damage detection (8-oxo-dG antibodies). In 2006, Trevigen will be launching Comet Assay Control Cells and a UVssDNA ELISA Kit, as well as other highly anticipated products. Trevigen looks forward to serving your DNA damage research needs. For more information, please call 1-800-873-8443 or visit our website at: http://www.trevigen.com Thanks, Michael Elliott Trevigen,Inc. Posted 1/18/2006
		Tulip BioLabs, Inc.
		Provides antibodies to poly(ADP-ribose), including a unique IgY antibody.
		Understanding Xeroderma Pigmentosum
		The booklet "Understanding Xeroderma Pigmentosum" is now available on the internet. This booklet provides information about XP written in plain English. It may be useful for patients, their families, educators, students, health professionals, media inquiries and others interested in learning more about XP. Revised 10/27/99
		UNITED KINGDOM XERODERMA PIGMENTOSUM SUPPORT GROUP
		We are pleased to announce the opening of the UK XP Support Group Website at http://xpsupportgroup.org.uk The site gives up to date information that is held by the Support Group as well as details of forthcoming events and Newsletters. Posted 10/11/2000
		Virtual Cell (VC) Radiobiology Software
		Virtual Cell (VC) is a complete computer program to simulate radiation effects in a homogeneous population of cells exposed to ionizing radiation. Output from the VC program includes information on DSB rejoining kinetics (FAR or unrepaired DSBs as a function of time), the yield of lethal and non-lethal mutations, and probability of oncogenic transformation or cell killing as a function of dose and dose rate. This program has been developed by Pacific Northwest National Laboratory and is available for use at the indicated website.
		XERODERMA PIGMENTOSUM SOCIETY
		The US XP Society is an active non-profit group involved in education, fund raising, and providing information for XP patients worldwide. They run Camp Sundown a summer camp with activities in the evening and night for XP patients and their families. Their website is http://www.xps.org Revised 10/11/2000

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